Bexarotene increases uptake of radioiodide in metastases of differentiated thyroid carcinoma
نویسندگان
چکیده
منابع مشابه
Radioiodine therapy after pretreatment with bexarotene for metastases of differentiated thyroid carcinoma.
OBJECTIVE To evaluate the effects of pretreatment with the retinoid X receptor (RXR) agonist bexarotene on the efficacy of radioiodine therapy for metastases of differentiated thyroid carcinoma (DTC) with limited uptake of radioiodine (I-131). DESIGN An open prospective intervention study. METHODS Eight patients with metastases of DTC, with insufficient uptake of I-131 who showed increased ...
متن کاملUncommon metastases from differentiated thyroid carcinoma.
Differentiated thyroid carcinoma (DTC) usually behaves in an indolent manner with low metastatic potential. The major sites of distant metastases are the lung and bone. Metastases to the brain, eye, breast, liver, kidney, muscle and skin are rare or relatively rare. These metastases have almost always appeared in patients with advanced disease and are often associated with poor prognosis but ov...
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The presence of distant metastases from differentiated thyroid carcinoma decreases the 10-year survival of patients by 50%. Bone metastases represent a frequent complication especially of follicular thyroid cancer and severely reduce the quality of life causing pain, fractures, and spinal cord compression. Diagnosis is established by correlating clinical suspicion with imaging. Imaging is essen...
متن کاملEvaluation of Treatment of Differentiated Carcinoma of Thyroid.
The treatment of patient with differentiated carcinoma of thyroid consists of three stages, surgery, I 1.1.i ablation and hormone therapy. To avoid the problems mentioned in the article, initially the patient should have thyroid scan, T.1 , T4, thyroglobulin estimation and a chest x-ray, prior to surgery which should be carried out by a competent surgeon, in order that total thyroidectomy can b...
متن کاملRegional metastases in well-differentiated thyroid carcinoma: pattern of spread.
OBJECTIVES/HYPOTHESIS To determine the pattern of spread of WDTC to regional lymph nodes, in patients who presented with clinically positive nodes. STUDY DESIGN Retrospective chart review. MATERIALS AND METHODS Between October 2001 and December 2006, a total of 27 consecutive patients (12 males, 15 females) with clinical evidence of cervical metastasis of well-differentiated thyroid carcino...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2006
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.1.02123